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Polynucleotides

Polynucleotides

A regenerative injectable treatment designed to improve skin quality, hydration, and natural tissue renewal.

The focus is on skin health, gradual improvement, and long-term revitalisation rather than instant or artificial results.

What are polynucleotides?

Polynucleotides are biotechnologically purified DNA fragments used in aesthetic medicine for skin biorepair.

Their role is not to “fill” the skin, but to stimulate the skin’s own natural regenerative processes.

The treatment is medically supervised and individually tailored to the condition and needs of the skin.

How do polynucleotides work?

Polynucleotides are biotechnologically purified DNA fragments used in aesthetic medicine for skin biorepair.

Their role is not to “fill” the skin, but to stimulate the skin’s own natural regenerative processes.

The treatment is medically supervised and individually tailored to the condition and needs of the skin.

How do polynucleotides work?

Polynucleotides support skin regeneration at a cellular level by:

  • stimulating fibroblast activity and collagen production
  • improving deep skin hydration
  • reducing oxidative stress and supporting tissue recovery

Over time, the skin becomes more elastic, smoother, and more resilient, with a natural and refreshed appearance.

Indications for polynucleotide treatment

  • dehydrated and tired-looking skin
  • loss of elasticity and firmness
  • fine lines and early signs of ageing
  • dark circles and poor skin quality under the eyes
  • skin recovery after aesthetic or dermatological procedures
  • prevention before more pronounced signs of ageing appear

Treatment areas

  • face
  • under-eye area
  • neck and décolletage
  • hands

What does the treatment involve?

The treatment begins with a consultation and skin assessment. Polynucleotides are injected into the superficial layers of the skin using a fine needle.

The procedure takes approximately 20–30 minutes. Downtime is minimal, allowing a quick return to daily activities.

Aftercare

  • avoid makeup, sauna, and intense physical activity for the first 24 hours
  • use sun protection (SPF)
  • follow personalised aftercare instructions provided by your doctor

How many treatments are needed?

For optimal results, a course of 2–4 treatments is recommended, spaced 2–3 weeks apart.

Results develop gradually and are cumulative, with visible improvement in skin quality over time.

FAQ – frequently asked questions

Is the treatment painful?

The treatment is generally well tolerated, with minimal discomfort.

Are there any side effects?

Mild papules, redness, or small bruises may occur and usually resolve within a few days.

Are polynucleotides dermal fillers?

No. Polynucleotides do not add volume. They improve skin quality, structure, and resilience.

Can polynucleotides be combined with other treatments?

Yes. They are often combined with other aesthetic or regenerative treatments as part of an individual treatment plan.

Polynucleotides are ideal for patients seeking a natural, gradual, and medically based approach to skin regeneration.

For personalised advice and a treatment plan, a consultation with a doctor is recommended.

Why choose 4CLINIC

Highly qualified and experienced professionals
Highly qualified and experienced professionals
State-of-the-art medical equipment
State-of-the-art medical equipment
Simple and accessible appointment booking
Simple and accessible appointment booking
Individualized approach
Individualized approach
Patient safety
Patient safety
Comprehensive support for patients at every stage of treatment
Comprehensive support for patients at every stage of treatment